Comprehensive genomic profiling service for haematological malignancies and sarcomas; to guide diagnosis, prognosis and treatment selection and personalise patients’ treatment plans.1–3

Comprehensive assessment in a single test

FoundationOne Heme comprehensively analyses the cancer genome to identify clinically relevant genomic alterations in haematological malignancies and sarcomas.1,2 

Delivers insights in a single test, thus saving time and avoiding repeat biopsy versus sequential biomarker testing1

Integrated DNA and RNA sequencing helps identify common, rare, and novel gene fusions and rearrangements1,2

Distribution of rearrangements called by detection method2

 

Supports clinical decision-making

A clear, in-depth report supports your clinical decision-making by providing insights on the genomic profile of your patient as well as associated targeted therapies, immunotherapies and relevant clinical trials. The report also highlights important disease-relevant genes with no reportable alterations identified and genomic alterations associated with potential resistance to therapy, to help rule out ineffective treatment.23

Reports four main classes of alterations spanning the DNA of 406 genes and the RNA of 265 genes in just 3 weeks following receipt of the sample at our laboratory1

 

Personalises treatment plans in haematological malignancies

FoundationOne Heme enables guideline-recommended testing to help guide diagnosis, prognosis and treatment selection, with the potential to improve patient outcomes.1,4–17  

Using FoundationOne Heme for haematological malignancies

Personalises treatment plans for sarcomas

FoundationOne Heme helps guide diagnosis, prognosis and treatment selection, with the potential to improve outcomes for sarcoma patients.1,3,18–20

High clinical utility in paediatric patients

  1. FoundationOne Heme is for haematological malignancies and sarcomas, which have relatively high incidences among malignancies in the paediatric population18,35
  2. FoundationOne Heme integrates DNA and RNA sequencing to identify complex genomic rearrangements, which are characteristic of haematological malignancies and sarcomas in paediatric patients1,13,35–38
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Order FoundationOne Heme

Experience how FoundationOne Heme can guide diagnosis, prognosis and treatment selection, and help personalise your patients’ treatment plans.1–3

FoundationOne Heme samples can be shipped to our Penzberg (Germany) or Cambridge (US) laboratories for patients in the EU or the rest of the world, respectively, enabling more patients to benefit from comprehensive genomic profiling with FoundationOne Heme.

Acceptable specimen types:

1. For haematological malignancies, multiple specimen types are acceptable; FoundationOne Heme has been validated with blood, bone marrow aspirate and FFPE tissue samples1,39

2. For sarcoma, please use FFPE tissue samples39

3. Our dedicated client service team offers information and support to ensure specimen requirements for analysis are met

 

*Base substitutions, insertions or deletions, copy number alterations and gene rearrangements.

Peripheral blood and bone marrow aspirate must be received the day after collection for optimal analysis as sensitivity of detection may degrade with time. Samples arriving later will result in a Qualified Report. FFPE block or slides are also accepted.

AML, acute myeloid leukaemia. ALL, acute lymphoblastic leukaemia. CLL, chronic lymphocytic leukaemia. GIST, gastrointestinal stromal tumours. DLBCL, diffuse large B-cell lymphoma. FFPE, formalin-fixed paraffin-embedded. MDS, myelodysplastic syndrome. MM, multiple myeloma. MPN, myeloproliferative neoplasms. MSI, microsatellite instability. RMS, rhabdomyosarcoma. TKI, tyrosine kinase inhibitor. TMB, tumour mutational burden. 

References
  1. FoundationOne®Heme Technical Specifications, 2019. Available at: www.foundationmedicine.com/genomic-testing/foundation-one-heme (Accessed July 2020).
  2. He J et al. Blood 2016; 127: 3004–3014.
  3. Gounder M et al. Presented at ASCO Annual Meeting 2017, Chicago (Illinois), USA: Abstract #11001 and oral presentation.
  4. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Acute Lymphoblastic Leukaemia. V.1.2018, 2018. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  5. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Acute Myeloid Leukaemia. V.1.2019, 2019. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  6. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Myelodysplastic Syndromes. V.2.2019, 2018. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  7. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Multiple Myeloma. V.2.2019, 2018. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  8. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). B-cell Lymphoma. V.1.2019, 2018. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  9. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). T-cell Lymphoma. V.2.2019, 2018. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  10. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Myeloproliferative Neoplasms. V.2.2019, 2018. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  11. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Chronic Lymphocytic Leukaemia. V.5.2019, 2018. Available at: https://www.nccn.org/professionals/physician_gls/default.aspx (Accessed July 2020).
  12. Morley S et al. Blood 2015; 126: 3898.
  13. Kobos R et al. Presented at ASH Annual Meeting 2016, San Diego (California), USA: Abstract 1605.
  14. He J et al. Presented at ASH Annual Meeting 2015, Orlando (Florida), USA: Abstract 2651.
  15. Galanina N et al. Cancers (Basel) 2018; 11.pii: E11.
  16. Goodman AM et al. JCO Precis Oncol 2017. doi: 10.1200/PO.16.00004. 
  17. Heuck C et al. Blood 2015; 126: 369.
  18. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Soft Tissue Sarcoma. V.2.2019, 2019. Available at: https://www.nccn.org/professionals/physician_gls/recently_updated.aspx (Accessed July 2020).
  19. Groisberg R et al. Oncotarget 2017; 8: 39254–39267.
  20. Doyle LA et al. Cancer 2014; 120: 1763–1774.
  21. Cote GM et al. Oncologist 2018; 23: 234–242.
  22. Chmielecki J et al. Cancer Res 2017; 77: 509–519.
  23. Data on file: FoundationOne®Heme Sample Report. 2018.
  24. Chavan SS et al. Blood Cancer J 2017; 7: e535.
  25. Severson EA et al. Presented at ASH Annual Meeting 2017, Atlanta (Georgia), USA: Abstract 476.
  26. Bustoros M et al. Am Soc Clin Oncol Educ Book 2017; 37: 548–560.
  27. Bolen J et al. Blood 2017; 130: 2729.
  28. Grzegorz S et al. Blood 2007; 110: 2067.
  29. Rossi D et al. Clin Cancer Res 2009; 15: 995–1004.
  30. Zenz T et al. J Clin Oncol 2010; 28: 4473–4479.
  31. Woyach JA et al. J Clin Oncol 2017; 35: 1437–1443.
  32. VITRAKVI® (larotrectinib) Prescribing Information. Available at: https://www.loxooncology.com/docs/general/vitrakvi.pdf (Accessed July 2020).
  33. Vaishnavi A et al. Cancer Discov 2015; 5: 25–34.
  34. GLEEVEC® (imatinib mesylate) Prescribing Information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021588s024lbl.pdf (Accessed July 2020).
  35. Tarlock K et al. Oncotarget 2018; 9: 26417–26430.
  36. Severson EA et al. Oncologist 2019; 24: 372–374.
  37. Chmielecki J et al. Cancer Res 2017; 77: 509–519.
  38. Pavlick D et al. Pediatr Blood Cancer 2017; 64: e26433.
  39. FoundationOne®Heme Specimen Instructions, 2018. Available at: https://assets.ctfassets.net/vhribv12lmne/36S2Vq3BPqwaTLoww8gerj/78a3f27012a3b3ea9e3064561dc22a02/F1H_Specimen_Instructions.pdf (Accessed July 2020).